You can find this city located near the Mississippi River just east of St. Louis, Missouri. What makes Alton such a special fall getaway is the fact that it is one of the hidden gems in the American Midwest. One of the best places to see the local fall foliage is along the Meeting of the Great Rivers National Scenic Byway. You can even check out local apple orchards during the peak of the harvest season. Haunted walking tours and fall festivals are also regularly staged in Alton during this time of year.